Executive Summary Synthetic cannabinoid receptor agonists (SCRAs)—commonly known as “Spice,” “K2,” or “herbal incense”—represent one of the most unpredictable and dangerous classes of novel psychoactive substances to emerge in the past two decades. Unlike natural cannabis, which contains the partial agonist tetrahydrocannabinol (THC), SCRAs are full agonists at CB₁ receptors in the brain, producing effects that are […]
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